Kiyosumi Shibata Selected Research

leucyl-cystinyl aminopeptidase

12/2021	Placental Leucine Aminopeptidase as a Potential Specific Urine Biomarker for Invasive Ovarian Cancer.
4/2007	Essential role of placental leucine aminopeptidase in gynecologic malignancy.
3/2006	A novel role for placental leucine aminopeptidase (P-LAP) as a determinant of chemoresistance in endometrial carcinoma cells.
11/2004	Placental leucine aminopeptidase (P-LAP) expression is associated with chemosensitivity in human endometrial carcinoma.
8/2004	Regulatory role of membrane-bound peptidases in the progression of gynecologic malignancies.
1/2004	Expression of placental leucine aminopeptidase is associated with a poor outcome in endometrial endometrioid adenocarcinoma.
4/2003	Possible role of placental leucine aminopeptidase in the antiproliferative effect of oxytocin in human endometrial adenocarcinoma.

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Kiyosumi Shibata Research Topics

Disease

71	Neoplasms (Cancer) 02/2021 - 01/2003
47	Carcinoma (Carcinomatosis) 02/2021 - 01/2002
24	Ovarian Neoplasms (Ovarian Cancer) 12/2021 - 04/2005
13	Neoplasm Metastasis (Metastasis) 01/2020 - 07/2004
13	Ovarian Epithelial Carcinoma 07/2019 - 04/2003
13	Endometrial Neoplasms (Endometrial Cancer) 01/2018 - 08/2003
11	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2020 - 03/2008
9	Adenocarcinoma 06/2016 - 01/2003
6	Endometrioid Carcinoma 04/2010 - 03/2003
5	Rupture 10/2014 - 01/2009
4	Choriocarcinoma 01/2017 - 08/2003
3	Teratoma (Teratoid Tumor) 12/2019 - 01/2013
3	Squamous Cell Carcinoma (Epidermoid Carcinoma) 12/2019 - 05/2004
3	Ascites 12/2019 - 11/2007
3	Residual Neoplasm 05/2016 - 01/2012
3	Lymphatic Metastasis 01/2014 - 01/2005
3	Mucinous Adenocarcinoma (Mucinous Carcinoma) 11/2009 - 10/2006
2	Hydatidiform Mole (Molar Pregnancy) 05/2020 - 01/2017
2	Carcinogenesis 12/2019 - 03/2005
2	Endometriosis 01/2019 - 01/2006
2	Hypoxia (Hypoxemia) 07/2018 - 01/2008
2	Infections 05/2018 - 10/2010
2	Sarcoma (Soft Tissue Sarcoma) 03/2018 - 01/2015
2	Death (Near-Death Experience) 02/2017 - 04/2015
2	Melanoma (Melanoma, Malignant) 09/2014 - 02/2010
2	Lung Neoplasms (Lung Cancer) 09/2014 - 04/2010
2	Hepatocellular Carcinoma (Hepatoma) 01/2014 - 09/2011
2	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 01/2013 - 05/2012
1	Pre-Eclampsia (Preeclampsia) 01/2022
1	Gestational Trophoblastic Disease (Trophoblastic Neoplasms, Gestational) 05/2020

Drug/Important Bio-Agent (IBA)

14	Paclitaxel (Taxol)FDA LinkGeneric 11/2017 - 11/2004
13	Proteins (Proteins, Gene)FDA Link 01/2020 - 04/2003
11	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA 02/2010 - 05/2002
10	EnzymesIBA 05/2011 - 04/2003
10	Complementary DNA (cDNA)IBA 11/2009 - 04/2003
9	Peptides (Polypeptides)IBA 01/2016 - 03/2003
8	Carboplatin (JM8)FDA LinkGeneric 05/2020 - 11/2004
8	Cisplatin (Platino)FDA LinkGeneric 05/2020 - 03/2006
8	PlatinumIBA 01/2020 - 11/2004
8	ParaffinIBA 12/2019 - 01/2004
8	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/2018 - 12/2003
8	Angiotensin IIIBA 05/2011 - 08/2003
7	leucyl-cystinyl aminopeptidaseIBA 12/2021 - 04/2003
7	Small Interfering RNA (siRNA)IBA 05/2020 - 01/2007
7	GlypicansIBA 09/2014 - 01/2010
6	Formaldehyde (Formol)FDA Link 12/2019 - 01/2004
6	Indicators and Reagents (Reagents)IBA 07/2018 - 04/2008
5	Cadherins (E-Cadherin)IBA 03/2013 - 05/2003
4	AminopeptidasesIBA 01/2022 - 12/2003
4	Biomarkers (Surrogate Marker)IBA 12/2021 - 03/2014
4	Pharmaceutical PreparationsIBA 06/2016 - 02/2010
4	Capsules (Microcapsules)IBA 10/2014 - 12/2011
4	AntigensIBA 09/2014 - 08/2011
4	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 06/2010 - 04/2008
4	Neprilysin (Neutral Endopeptidase)IBA 03/2005 - 04/2003
4	Oxytocin (Pitocin)FDA LinkGeneric 08/2004 - 04/2003
3	Protein Subunit VaccinesIBA 02/2021 - 01/2014
3	MicroRNAs (MicroRNA)IBA 02/2021 - 08/2014
3	SpectrinIBA 05/2020 - 01/2012
3	ubenimexIBA 03/2008 - 05/2007
3	Chemokine CXCL12IBA 01/2008 - 07/2004
3	Endothelin-1 (Endothelin 1)IBA 03/2005 - 08/2004
3	Leucyl Aminopeptidase (Peptidase S)IBA 01/2005 - 08/2003
3	Peptide Hydrolases (Proteases)FDA Link 08/2004 - 05/2004
3	Glutamyl Aminopeptidase (Aspartyl Aminopeptidase)IBA 08/2004 - 08/2003
2	Peptide Hormones (Polypeptide Hormones)IBA 01/2022 - 01/2004
2	Hormones (Hormone)IBA 01/2022 - 04/2013
2	Biological ProductsIBA 12/2019 - 08/2004
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 05/2016
2	Plasminogen Activators (Plasminogen Activator)IBA 01/2019 - 01/2008
2	ChemokinesIBA 01/2019 - 01/2007
2	Messenger RNA (mRNA)IBA 03/2018 - 01/2008
2	Fluorouracil (Carac)FDA LinkGeneric 01/2017 - 06/2008
2	Fibronectins (Fibronectin)IBA 08/2014 - 02/2009
2	Metalloproteases (Metalloproteinases)IBA 08/2014 - 05/2004
2	taxaneIBA 01/2014 - 10/2012
2	Basic Helix-Loop-Helix Transcription FactorsIBA 02/2013 - 01/2006
2	Type 1 Angiotensin ReceptorIBA 05/2011 - 04/2005
2	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 05/2011 - 03/2006
2	Glucose (Dextrose)FDA LinkGeneric 10/2010 - 01/2007
2	ProdrugsIBA 02/2010 - 02/2008
2	paclitaxel 2'-ethylcarbonateIBA 02/2010 - 02/2008
2	Matrix Metalloproteinases (MMPs)IBA 01/2009 - 05/2003
2	Matrix Metalloproteinase 2 (Gelatinase A)IBA 01/2009 - 03/2005
2	CD13 Antigens (Alanine Aminopeptidase)IBA 03/2008 - 05/2007
2	ethyl monochloroacetate (EMCA)IBA 01/2007 - 07/2004
2	AngiotensinsIBA 03/2006 - 01/2005
2	Conditioned Culture MediaIBA 03/2005 - 01/2005
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 05/2020
1	liposomal doxorubicin (Doxil)FDA Link 05/2020

Therapy/Procedure

20	Drug Therapy (Chemotherapy) 02/2021 - 11/2004
13	Therapeutics 02/2021 - 04/2005
5	Lymph Node Excision (Lymph Node Dissection) 07/2020 - 06/2008
5	Radiotherapy 07/2018 - 03/2008
4	Hysterectomy 05/2020 - 01/2006
4	Cytoreduction Surgical Procedures 01/2019 - 01/2006
3	Chemoradiotherapy 01/2017 - 05/2016
2	Cystectomy 07/2019 - 04/2013
2	Immunotherapy 09/2014 - 09/2011
2	Adjuvant Chemotherapy 09/2012 - 12/2011